ACES - ACE inhibitors Combined with Exercise for hypertensive Seniors (R01AG056769)
The purpose of this project is to conduct a randomized, controlled trial (RCT) to determine if choice of antihypertensive medication influences changes in functional status and other cardiovascular risk factors among older persons with hypertension.
ACE2 as a Novel Therapeutic to Preserve Physical Function in Late Life (R01AG054538)
This project is evaluating the impact of directly activating ACE2 in older rats to evaluate effects on the preservation of physical function.
A Sex Difference Approach to Evaluating Resilence as a Predictor of Healthspan in Mice (R01AG057434)
The goal of the proposed research is to develop a standardized challenge or panel of challenges and their accompanying recovery metrics that will be informative about the healthspan impact of putative health-extending interventions when administered in early-to-mid life.
Resveratrol and Exercise to Treat Functional Limitations in Late Life (R21AG049974)
The overarching objective of this project is to evaluate the safety and efficacy of an intervention combining resveratrol supplementation and physical exercise among sedentary persons aged > 65 years objectively-measured functional impairments